Exploring the Tumor Microenvironment of Invasive Lobular Carcinoma With Jason Mouabbi, MD

In this interview from the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Oncology Data Advisor Editorial Board member Dr. Jason Mouabbi, Assistant Professor of Medicine at MD Anderson Cancer Center, discusses the poster he presented on “The Multiomic Tumor Microenvironment Landscape of Invasive Lobular Carcinoma of the Breast,” including:

  • The known role of the tumor microenvironment (TME) in invasive lobular carcinoma progression and therapeutic response
  • The limitations of traditional histopathological methods in dissecting the complexity and heterogeneity of the TME
  • His team’s approach using single-cell spatial phenotyping and multiplex immunofluorescence integrated with RNA sequencing to evaluate the TME
  • How further evaluation of the TME with this approach can lead to the development of personalized therapeutic strategies for invasive lobular carcinoma
  • And more!

About Dr. Mouabbi

Jason Mouabbi, MD, is an Assistant Professor in the Department of General Oncology and the Department of Breast Medical Oncology at The University of Texas MD Anderson Cancer Center, where he specializes in lobular breast cancers. His research focuses on the management of breast cancer subtypes and their impact on treatment. Dr. Mouabbi has been the recipient of multiple honors and awards, including the Guiding Researchers and Advocates to Scientific Partnerships (GRASP) Advocate Choice Award and the Lester & Sue Smith Breast Cancer Award of Excellence in 2021.

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