· Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of tumors that originate in the lip/oral cavity, hypopharynx, oropharynx, nasopharynx, and larynx. An estimated 66,630 new cases are diagnosed in the United States annually, and 14,620 people die of the disease (Siegel et al, 2021). Historically, HNSCC has been ...