Cemiplimab Approval for Locally Advanced/Metastatic Basal Cell Carcinoma

Recently, the FDA granted approval to cemiplimab (Libtayo®, Regeneron Pharmaceuticals) for the treatment of patients with locally advanced or metastatic basal cell carcinoma (BCC) who were previously treated with a hedgehog pathway inhibitor (HHI) or who are ineligible for HHI therapy. In this interview, Karl Lewis, MD, Professor of Medical Oncology at the University of Colorado Anschutz Medical Campus and one of the investigators of Study 1620 (NCT03132636), on which the approval was based, spe...

Cemiplimab-rwlc Approved for Locally Advanced/Metastatic Basal Cell Carcinoma

The FDA has now approved cemiplimab-rwlc (Libtayo®, Regeneron Pharmaceuticals) for patients with locally advanced or metastatic basal cell carcinoma (BCC) who received prior treatment with a hedgehog pathway inhibitor (HHI) and those who are ineligible for HHI therapy. Cemiplimab is the first immunotherapy to be approved for patients with advanced BCC. "Cemiplimab, an antibody to programmed cell death protein 1 (PD-1), is an established therapy approved for treatment of advanced cutaneous squamo...

Pathogenesis May Impact Survival Outcomes for Sinonasal Squamous Cell Carcinoma

The prognosis for sinonasal squamous cell carcinoma (SCC) is dismal, with the 5-year overall survival rate estimated to be around 30% to 55%. Sinonasal SCC pathogenesis can result from either de novo or inverted papillomas (IPs)—benign, aggressive neoplasms of the nasal cavity or paranasal sinuses. However, there is little research on whether or not the pathogenesis of sinonasal SCC has an impact on patient outcomes. According to a study recently published in JAMA Otolaryngology-Head & Neck ...

Trunk and Extremity Melanoma Debate: Similar Outcomes for Mohs Micrographic Surgery Versus Wide Local Excision

Survival outcomes did not change significantly for patients with melanoma of the trunk or extremity when treated with Mohs micrographic surgery (MMS) compared with wide local excision, according to the results of a retrospective cohort study published recently in JAMA Dermatology. The retrospective cohort study was designed because previous studies indicated differences in overall survival outcomes for patients with head and neck cancers. However, this study indicates that those results do not a...

Neoadjuvant Ipilimumab/Nivolumab for Locally Advanced/Oligometastatic Melanoma: Emilia Cocorocchio, MD

With high rates of metastasis and progression, locally advanced/oligometastatic melanoma is a challenging disease to treat. According to results of a trial recently presented at the European Medical Society for Oncology (ESMO) Virtual Congress, neoadjuvant ipilimumab/nivolumab is a safe and effective treatment for patients with this disease. In this interview with i3 Health, lead study author Emilia Cocorocchio, MD, discusses the benefits of neoadjuvant ipilimumab/nivolumab and shares advice for...

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