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Delivering Immunotherapeutics Intratumorally: Safe for Treating Cancer?

Intravenous administration of chemotherapy is the conventional method of delivery. However, several issues arise with this method, including insufficient drug penetration into the tumor tissue. Intratumoral injections of immunotherapies directly into the tumor have been a possible solution to this problem, and, according to a recent study, results of which are published in JAMA Network Open, this technique has been found to be a viable option for a variety of histological conditions and target o...

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Immunotherapy Safe for Patients With HIV and Advanced Cancer

Patients infected with HIV are at increased risk of cancer. For example, Kaposi sarcoma is 500 times more likely to occur in patients with HIV than in the general population. Because of their compromised immune systems, patients with HIV are not able to partake in immunotherapy clinical trials. However, researchers at Georgetown University have now found that immunotherapy is quite successful in treating patients with HIV and advanced-stage cancers, producing side effects in only a slight percen...

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Non-Canonical NF-kB Pathway Improves Radiotherapy Results

A new study published in Immunity demonstrates that radiation therapy interacts with a patient's innate and adaptive immune responses to improve cancer treatment differently than previously thought. In recent years, researchers have discovered that radiotherapy does more than simply attack tumor cells; it also causes secondary immune responses that can greatly enhance anti-tumor immunity. A focus of investigation in these secondary immune responses has been the nuclear factor-kB (NF-kB) sig...

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Cancer Treatment or Hospice Care—Why Choose?

Unfortunately, Medicare patients have to make the choice between receiving cancer treatment or hospice care; they cannot have both due to cost constraints. However, through the Veterans Health Administration (VHA), cancer treatment and hospice care can occur simultaneously if a patient opts for both. This concurrent treatment can be very valuable to patients and their loved ones; it is important to have the option to receive both treatments at once. "Often, Medicare patients with terminal cancer...

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Device Can Predict Propensity for Metastasis

Disease growth to distant tissues and organs is the leading cause of cancer-related death. Up until recently, there was only technology available to detect when cancer had already metastasized; however, scientists at University of California San Diego School of Medicine developed sensors that have the capability of detecting and measuring cancer's growth potential. "Cancer would not be so devastating if it did not metastasize. Although there are many ways to detect metastasis once it has occurre...

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Diabetes and Antihypertensive Drug Combo Kills Cancer Cells

Typically, metformin is used in patients with diabetes to lower blood sugar levels. In treating diabetes, metformin is administered in too low of a dose to fight cancer. However, researchers have recently discovered that when taken with syrosingopine, a drug used to treat hypertension, metformin's ability to kill cancer is enhanced. In a study published in Cell Reports, researchers found metformin and syrosingopine work together to block a crucial step in cancer's energy production process, elim...

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Artificial Intelligence Predicts Symptoms in Cancer Patients

Cancer patients have to deal not only with symptoms of cancer and adverse effects due to treatments, but also with comorbidities such as depression, anxiety, and sleep disturbance. Because these symptoms greatly reduce patients' quality of life, it is imperative to combat them. Scientists have discovered how to better treat these symptoms by utilizing artificial intelligence (AI) in order to predict their presence and severity in cancer patients before they occur, allowing doctors to identify hi...

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Enzyme Identified as Contributor to Cancer Growth

A stem cell enzyme, adenosine deaminase associated with RNA1 (ADAR1), has been identified as an active component of over 20 types of cancer, including liver, breast, and leukemia. A new test to detect ADAR1 could have the capability of being a potential way to screen for cancer. Adenosine deaminase associated with RNA1 is one of three enzymes encoded by the ADAR genes. Because they modify nucleotides within double-stranded RNA molecules, in turn regulating gene expression, these enzymes are esse...

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PTSD Increases Risk for Heart Disease and Cancer

Because post-traumatic stress disorder (PTSD) can place the body in a constant state of alarm called hyperarousal, those with PTSD are at risk for developing an array of comorbidities, including cardiovascular, respiratory, gastroenteric, and sleep disorders. Do PTSD patients also have an increased risk of developing cancer? In a study published in the Journal of Neuroscience Research, scientists have come closer to answering that question. When the researchers studied 84 participants diagnosed ...

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3D Imaging Technique Reveals Origins of Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers, with a five-year survival rate of 7%. With early diagnosis, however, that percentage can rise to between 20% and 35%. By developing a new technology to analyze three-dimensional (3D) pancreatic tumor tissue samples, researchers have discovered ways in which the malignancies start and grow. The investigators' new technique can potentially be used for early diagnosis. "To investigate the origins of pancreatic cancer, we spent six years developing ...

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Killing Leukemia Cells by Disrupting Amino Acid Consumption

Researchers at Winship Cancer Institute of Emory University found that inhibiting amino acid metabolism hinders leukemia cell growth. The investigators report that ASCT2, a transporter enzyme that carries amino acids into cells, is a potential therapeutic target for cancer. "So far, little progress has been made in finding therapeutic targets in amino acid metabolic pathways that can be harnessed to kill cancer cells but spare normal cells," remarked Cheng-Kui Qu, MD, PhD, Professor in the Depar...

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Nutrition Supplements: Do They Do More Harm Than Good?

According to a new study, nutrition supplements may not be as beneficial as nutrients derived from food for reducing all-cause mortality. In fact, certain supplements taken in excess may actually promote some cancers. "As potential benefits and harms of supplement use continue to be studied, some studies have found associations between excess nutrient intake and adverse outcomes, including increased risk of certain cancers," remarked Fang Fang Zhang, MD, PhD, Associate Professor at the Friedman ...

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Emergency Departments’ Cancer Expertise Level Predicts Patient Outcomes

Cancer patients are frequent visitors of the emergency department for a myriad of cancer-related reasons, and several external factors can help predict patient outcomes. Researchers discovered that patients with cancer seeking emergency cancer-related treatment receive better outcomes when seen at a care facility with cancer expertise. In addition, they found that cancer expertise of an institution is more indicative of patient outcomes than continuity of care. In this study, published in Canadi...

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