Determining Patient Selection for CAR T-Cell Therapy in Multiple Myeloma With Beth Faiman, PhD, CNP

While chimeric antigen receptor (CAR) T–cell therapy has revolutionized the treatment landscape for multiple myeloma, the high demand for these efficacious therapies has made patient selection a challenge. At the recent International Myeloma Society Annual Meeting, Beth Faiman, a Nurse Practitioner at the Cleveland Clinic, presented a poster about a clinical factor scoring system that she and her colleagues have developed to aid in these decisions. In this follow-up interview with Oncology Data Advisor, Dr. Faiman explains how this innovative system works and the next steps to validate it and implement it into practice in the future.  

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Oncology Nursing Month With Maria Badillo and Sherry Adkins: Nursing Considerations for CAR T-Cell Therapy

Oncology Data Advisor™ · Nursing Considerations for CAR T-Cell Therapy With Maria Badillo and Sherry Adkins In honor of Oncology Nursing Month in May, Oncology Data Advisor is celebrating the stories of these essential members of the cancer care team. For this interview, editorial board member Maria Badillo, MSN, RN, OCN®, CCRP, speaks with Sherry Adkins, MSN, ANP-C, Advanced Practice Provider Supervisor at MD Anderson Cancer Center, about her groundbreaking research in the developm...

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First CAR T-Cell Therapy Approved for Mantle Cell Lymphoma

The FDA has now granted accelerated approval to brexucabtagene autoleucel (TecartusTM, Kite Pharma, formerly known as KTE-X19) for the treatment of adults with relapsed or refractory mantle cell lymphoma (MCL). Brexucabtagene autoleucel, a CD19-directed chimeric antigen receptor (CAR) T-cell therapy, is the first CAR T-cell therapy approved for this rare type of B-cell non-Hodgkin lymphoma. Efficacy was evaluated in the multicenter, open-label phase 2 ZUMA-2 trial (NCT02601313), which enrolled 7...

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CAR T-Cell Therapy: Oncology Nurses’ Educational Needs

Pre-activity assessment data from i3 Health's nursing continuing professional development (NCPD) activity "Understanding and Optimizing CAR T-Cell Therapy for Patients With B-Cell Malignancies" has revealed significant baseline knowledge gaps regarding the use of chimeric antigen receptor (CAR) T-cell therapy for the treatment of patients with B-cell malignancies. Of the 584 learners who took the pretest and began the activity, 539 saw it through to completion. The learners who completed the act...

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Preparing Nurses to Manage CAR T-Cell Therapy Adverse Events With Lindsey Bashaw, RN

Chimeric antigen receptor (CAR) T-cell therapy is a new form of immunotherapy in which a patient's own T cells are collected and genetically altered to target cancer cells. Although CAR T-cell therapy has shown encouraging clinical trial results in patients with acute lymphoblastic leukemia and B-cell lymphomas, they are associated with severe adverse events such as cytokine release syndrome, neurotoxicity, tumor lysis syndrome, and graft-versus-host disease. Many of the patients who receive CAR...

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CAR T-Cell Therapies: Survey of Oncology Nurses Reveals Much to Be Learned

​Chimeric antigen receptor (CAR) T-cell therapy is a form of immunotherapy in which a patient's own T cells are collected and genetically altered to target cancer cells. Although CAR T-cell therapies have shown encouraging results in patients with acute lymphoblastic leukemia and B-cell lymphomas, they are associated with several serious adverse events, including cytokine release syndrome, neurotoxicity, tumor lysis syndrome, and graft-versus-host disease.  In light of the growing use of CA...

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CAR T-Cell Therapy: New Treatment for Large B-Cell Lymphoma

Large B-cell lymphoma is an extremely destructive, invasive subtype of non-Hodgkin lymphoma. Often, patients with this malignancy have undergone several treatments that have not worked. New therapeutic approaches are necessary for relapsed/refractory disease. A breakthrough personalized treatment, CAR T-cell therapy may be an option for patients with relapsed/refractory large B-cell lymphoma. Patients undergo a process called leukapheresis, in which a patient's blood is collected and put through...

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B-Cell Malignancies: Treatment Advances in CAR T-Cell Therapy With Stephanie Jackson, MSN, RN, AOCNS®, BMTCN®

Outcomes have improved in recent years for patients with B-cell malignancies such as diffuse large B-cell lymphoma and B-cell acute lymphoblastic leukemia (ALL), but many patients continue to develop relapsed or refractory disease. In this interview with i3 Health, Stephanie Jackson, MSN, RN, AOCNS®, BMTCN®, Oncology Clinical Nurse Specialist at the Ronald Reagan UCLA Medical Center, discusses advances in chimeric antigen receptor (CAR) T-cell therapy, which has been shown to produce significant...

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New Insights into the Precise Function of CAR T Cells

​Chimeric antigen receptor (CAR) T-cell therapy modifies the patient's own T cells, otherwise known as natural killer cells or cytotoxic T lymphocytes, to enable the T cells to recognize and eliminate a target molecule, CD19, on the cancerous cells. While this form of immunotherapy has great potential in treating B-cell malignancies, relapse does occur in some patients. Researchers have gained new insights into the outcome and dynamics of CAR T-cell interactions in different anatomical sites, re...

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Bb2121: New CAR T-Cell Therapy for Multiple Myeloma

A phase 1 clinical trial reports that bb2121, a chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA), has shown antitumor activity in relapsed/refractory multiple myeloma. A form of immunotherapy, CAR T-cell therapy involves adding a CAR to the patient's cytotoxic T cells, transforming the T cells into CAR T cells. After this modification, which is done in the laboratory, the CAR T cells are reinjected into the patient's bloodstream, where they multiply and a...

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Multiple Myeloma: bb2121 CAR T-Cell Therapy With James Kochenderfer, MD

Chimeric antigen receptor (CAR) T-cell therapy has shown great promise in hematologic malignancies, with treatments currently FDA approved for aggressive, refractory non-Hodgkin lymphoma and for relapsed/refractory acute lymphoblastic leukemia in patients up to the age of 25. Now, a phase 1 clinical trial of bb2121, a CAR T-cell therapy targeting B-cell maturation antigen (BCMA), has demonstrated antitumor activity in patients with heavily pretreated multiple myeloma. In this interview with i3 H...

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HSCT: Improving Communication Between the Transplant Center and the Oncologist With Miguel-Angel Perales, MD

While hematopoietic stem cell transplant (HSCT) offers a curative treatment option for many patients, oncologists face unique challenges, including the underutilization of transplant, the need for improved communication between the transplant center and the community oncologist, and the implementation of CAR T-cell therapy. In this interview with i3 Health, Miguel-Angel Perales, MD, addresses these challenges and discusses the importance of clinical trial enrollment and innovative programs that ...

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Under Medicare, CAR T-Cell Therapy Now Available Nationwide

The Centers for Medicare & Medicaid Services (CMS) have finalized nationwide coverage of chimeric antigen receptor (CAR) T-cell therapy, replacing the previous policy under which the decision of treatment coverage was left to Medicare's regional administrators. "As the first type of FDA-approved gene therapy, CAR T-cell therapies are an important scientific advancement in this promising new area of medicine and provide treatment options for some patients who had nowhere else to turn," c...

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Treating Multiple Myeloma: Challenges, Solutions, and Research Advances With Carol Ann Huff, MD

​With a five-year survival rate of only 50.7%, multiple myeloma remains difficult to treat. In this interview with i3 Health, Carol Ann Huff, MD, Medical Director for the Johns Hopkins Kimmel Cancer Center, explores the challenges and research advances of myeloma treatment. She also gives advice on helping patients to find assistance with the prohibitive costs of treatment and on handling the difficulties involved in treating patients at smaller community cancer centers, including patients who l...

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