Perspectives on Metastatic and Castration-Resistant Prostate Cancer: A Discussion with Ulka Vaishampayan, MD

Oncology Data Advisor™ · Perspectives on Metastatic and Castration-Resistant Prostate Cancer With Ulka Vaishampayan, MD Selma Khenissi, MPS: Hello, welcome to Oncology Data Advisor. I'm Selma Khenissi from i3 Health. In honor of prostate cancer awareness month, we are here today with Dr. Ulka Vaishampayan, who will be discussing issues surrounding prostate cancer. Welcome. Ulka Vaishampayan, MD: Thank you for having me on this interview. I would like to bring our problems surroundin...

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Perspectives on Metastatic and Castration-Resistant Prostate Cancer: A Discussion with Ulka Vaishampayan, MD

Selma Khenissi, MPS: Hello, welcome to Oncology Data Advisor. I'm Selma Khenissi from i3 Health. In honor of prostate cancer awareness month, we are here today with Dr. Ulka Vaishampayan, who will be discussing issues surrounding prostate cancer. Welcome. Ulka Vaishampayan, MD: Thank you for having me on this interview. I would like to bring our problems surrounding prostate cancer to the forefront today. Especially with this being Prostate Cancer Awareness Month, we should be thinking about the...

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Darolutamide for Castration-Resistant Prostate Cancer: FDA Updates Prescribing Info

The FDA has added new overall survival and other secondary outcome data to the prescribing information for darolutamide (Nubeqa®, Bayer), an androgen receptor inhibitor which was approved for the treatment of nonmetastatic castration-resistant prostate cancer (CRPC) in 2019. The updates were based on the final analysis of the phase 3 ARAMIS trial (NCT02200614), led by first author Karim Fizazi, MD, Head of the Department of Cancer Medicine at the Institut Gustave Roussy in Villejuif, France. The...

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Rucaparib for BRCA-Mutated Castration-Resistant Prostate Cancer: Nicholas Vogelzang, MD

In this interview, Nicholas Vogelzang, MD, speaks with i3 Health about the recent FDA approval of rucaparib (Rubraca®, Clovis Oncology, Inc.) for the treatment of patients with metastatic BRCA-mutated castration-resistant prostate cancer (CRPC) who previously received one line of taxane-based chemotherapy and at least one line of androgen receptor-directed therapy. Dr. Vogelzang, Clinical Professor of Medicine at the University of Nevada School of Medicine and one of the investigators of the TRI...

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Olaparib Approved: HRR-Mutated Metastatic Castration-Resistant Prostate Cancer

The FDA has approved olaparib (LynparzaTM, AstraZeneca Pharmaceuticals LP) for adult patients with homologous recombination repair (HRR)–mutated metastatic castration-resistant prostate cancer (CRPC) who experience disease progression after treatment with enzalutamide or abiraterone acetate. In addition, the FDA approved two companion diagnostic devices: FoundationOne® CDx (Foundation Medicine, Inc.), for the identification of HRR gene alterations, and BRACAnalysis CDx®(Myriad Genetics, Inc...

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Rucaparib Approved: BRCA-Mutated Metastatic CRPC

The FDA has granted accelerated approval to rucaparib (Rubraca®, Clovis Oncology, Inc.) for patients with deleterious germline and/or somatic BRCA-mutated metastatic castration-resistant prostate cancer (CRPC) who have previously received one line of taxane-based chemotherapy and one or more lines of androgen receptor-directed therapy. The approval was based on TRITON2 (NCT02952534), a phase 2 clinical trial which enrolled 115 patients with BRCA-mutated metastatic CRPC. Patients received 600 mg ...

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The Current State of CRPC Management With Judd W. Moul, MD, FACS

In the past decade, much progress has been made in the management of castration-resistant prostate cancer (CRPC), with numerous new agents improving outcomes in patients with this disease. However, many challenges still remain. In this interview with i3 Health, Judd W. Moul, MD, FACS, Professor of Urologic Surgery at the Duke School of Medicine, discusses strategies that community oncologists and urologists can utilize to determine the best treatment for their patients. He also discusses the rol...

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Educational Need in Castration-Resistant Prostate Cancer

Due to the increase in treatment options for castration-resistant prostate cancer (CRPC) in recent years, some confusion exists over the optimal therapeutic approach. A number of factors must be considered in CRPC treatment, including patient health status, rate of disease progression and disease burden, presence of bone or visceral metastases, mechanism of action and tolerability of available agents, and prior lines of therapy and response. Baseline data collected from i3 Health's continuing me...

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Prostate Cancer: Adding Enzalutamide to First-Line Therapy

With around 170,000 men in the United States projected to be diagnosed with prostate cancer this year, it is the most common cancer in men. Androgen therapy is usually administered for progressive disease; however, hormone-sensitive prostate cancer can develop into castration-resistant prostate cancer, signifying treatment resistance to androgen deprivation therapy or to antiandrogens. There is a lack of understanding surrounding the transition from castration-sensitive to castration-resistant a...

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Knowledge Gaps Surrounding CRPC Risk Assessment, Treatment

Over the past few years, the treatment options for castration-resistant prostate cancer (CRPC) have increased to include novel hormone therapies, second-generation taxanes, immunotherapy, and bone-targeted and bone metastasis-targeted agents. Due to an absence of large prospective trials, clinical decision making needs to be based on many different factors, including optimal treatment sequences and combinations, patient health status (eg, asymptomatic or symptomatic), rate of disease progression...

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Treatment Selection Considerations in Castration-Resistant Prostate Cancer With Robert Dreicer, MD

Prostate cancer is the most common tumor type in men in the United States. Typically, androgen deprivation therapy (ADT) is administered for progressive disease. However, castration resistance or unresponsiveness to ADT or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be understood and represents a significant unmet need. Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate-re...

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Metastatic Castration-Resistant Prostate Cancer: Treatment Selection and Sequencing With Tanya Dorff, MD

Prostate cancer is the most common tumor type among men in the United States. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be understood and represents a significant unmet need. Metastatic castration-resistant prostate cancer (CRPC) is the primar...

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