Tucatinib Plus Trastuzumab Approved for Colorectal Cancer

The FDA has granted accelerated approval to tucatinib (Tukysa®, Seagen, Inc.) with trastuzumab for rat sarcoma (RAS) wild-type human epidermal growth factor receptor 2 (HER2)–positive unresectable or metastatic colorectal cancer (CRC) that has progressed following fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. "Patients with chemotherapy-refractory HER2-positive metastatic colorectal cancer receive limited clinical benefit with currently available therapies," said John Stric...

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Addressing Clinical Trial Accrual of Minority Patients With Donna Catamero, NP

At the recent International Myeloma Society (IMS) Annual Meeting, Donna Catamero, NP, the Associate Director of Myeloma Translational Research at Mount Sinai Hospital, presented her abstract regarding increasing clinical trial accrual of minority patients. In this interview, Ms. Catamero discusses her presentation, the disproportionate burden that minority patients experience, and why she believes the health care team should take action to create an equal space for everyone in the clinic.  

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Artificial Intelligence: Useful for Designing Clinical Trials

Due to lackluster recruiting techniques, a suboptimal number of patients are selected to participate in clinical trials. In addition, the researchers often have limited ability to observe and coach patients during clinical trials. These factors contribute to high clinical trial failure rates, which have a negative impact on the drug development cycle, not to mention 10 to 15 years and hundreds of millions of dollars wasted. However, scientists have proposed a potential solution to this problem: ...

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