Potential Drug Target for p53 Discovered

The p53 tumor suppressor protein is a crucial component to hindering cancerous growth; however, when this protein is mutated, cancer frequently occurs. Researchers at the University of Wisconsin-Madison reported that a regulator of the protein, known as the enzyme PIPK1-alpha, could be a potential therapeutic target. The researchers of the study, published in Nature Cell Biology, described the typical behavior of the p53 protein as being the "guardian of the genome" by activating the repair of D...
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Cell Repair Uses Chromosome Scanner to Protect Against Cancer

By identifying a type of scanner protein that is used to look for any damaged chromosomes, researchers at the University of Copenhagen have made a new discovery that illuminates the DNA repair process of homologous recombination (HR), which is important to cancer prevention. The cellular repair process, which is crucial for ridding cells of damaged DNA and preventing cancer, involves two repair systems: error-free homologous recombination (HR) and mutagenic non-homologous end-joining. Homologous...
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Damaged DNA Linked Directly to Malignant Diseases

Mutagenesis is caused not only by errors in DNA doubling but also by DNA damage. Just how many mutations are caused by environmental factors as opposed to internal mistakes? Scientists have come close to uncovering the answer to that question in a study published in Nature Genetics. "We decided to look at this problem from a different perspective and evaluated the contribution of the DNA damage to the accumulation of mutations," explained the study's lead author, Vladimir Seplyarskiy, PhD, of th...
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Accelerated Aging Linked to Breast Cancer Treatments

Cancer treatments such as chemotherapy and radiation work by damaging the DNA of cancer cells, thereby killing them. Unfortunately, it is impossible for these treatments to target only the diseased cells; therefore, surrounding healthy cells also suffer from DNA damage as a result of treatment. This DNA damage to healthy cells could have dire consequences. Findings from a study published in Cancer reveal that certain treatments for breast cancer increase patients' exposure to toxicities that may...
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