HPV-Linked Head and Neck Cancer: Biomarker Predicts Outcome

A biomarker that can be identified by blood test was discovered to be a potential indicator of prognosis for human papillomavirus (HPV)-associated oropharyngeal cancer. "Head and neck cancers that are caused by HPV infection tend to have a better overall outcome than head and neck cancers related to other factors like smoking and alcohol," said Gaorav Gupta, MD, PhD, Assistant Professor in the Department of Radiation at the University of North Carolina School of Medicine and senior author of the...
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Eliminating Cervical Cancer Worldwide: An Interview With Karen Canfell, DPhil

Cervical cancer is the fourth most common cancer in women globally, yet because it most often results from specific strains of the human papillomavirus (HPV) for which a vaccine is now available, it is becoming largely preventable. Addressing a call from World Health Organization (WHO) to eliminate cervical cancer as a public health problem, a team of researchers led by cancer epidemiologist Karen Canfell, DPhil, investigated whether it would be possible to wipe out this disease worldwide by the...
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Could Cervical Cancer Be Eliminated Worldwide by 2099?

‚ÄčCervical cancer is the fourth most common cancer in women, with approximately 570,000 cases diagnosed worldwide during the year 2018. Yet because this cancer most frequently results from specific strains of the human papillomavirus (HPV) for which a vaccine is now FDA-approved in individuals up to the age of 45, it is becoming largely preventable. With this in mind, the World Health Organization called last year for the elimination of cervical cancer as a public health problem. A team of Austra...
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The Bacterial Microbiome Plays a Role in Cervical Cancer

Almost all (99%) of cervical cancers stem from certain strains of human papillomavirus (HPV) that cause precancerous lesions. In a recent study, scientists report that the cervical bacterial microbiome plays a crucial role in the development of HPV and, in turn, in the development of cervical cancer. In the study, which was published in mBio, the journal of the American Society for Microbiology, the investigators used cytobrush swabs to collect samples from cervical lesions from 144 Tanzanian wo...
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HPV+ Without CIN: Still at Risk for Cervical Cancer

A cellular abnormality called cervical intraepithelial neoplasia (CIN) is a precursor for cervical cancer. However, scientists have now found that women who are positive for human papillomavirus (HPV) and negative for CIN are still at a very high risk for developing cervical cancer. In a study published in the journal Cancer, researchers identified 576 healthy women through the National Cervical Screening Registry who were screened between 2005 to 2007 and tested negative for CIN. During a follo...
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