World Lung Cancer Day With Beth Sandy, MSN, CRNP, and Corey Langer, MD

On August 1st, Oncology Data Advisor hosted a live panel discussion in honor of World Lung Cancer Day, featuring Beth Sandy, MSN, CRNP, and Corey Langer, MD, both of the University of Pennsylvania Abramson Cancer Center. Ms. Sandy and Dr. Langer discussed the improvements in survival that have occurred in recent years due to the development of novel therapies, groundbreaking developments in the fields of immunotherapy and targeted therapy, and exciting advances that lay on the horizon for patients with lung cancer in the coming years.  

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The Burden of Myelosuppressive Hematologic Adverse Events in Small Cell Lung Cancer: Jerome Goldschmidt, MD

For patients with extensive-stage small cell lung cancer (SCLC), cytotoxic chemotherapy remains a mainstay of treatment. However, myelosuppressive hematologic adverse events such as anemia, neutropenia, and thrombocytopenia pose a significant challenge to care. In a study recently presented at the 63rd American Society of Hematology (ASH) Annual Meeting & Exposition in Atlanta, Georgia, a team of researchers led by Dr. Jerome Goldschmidt, medical oncologist at Blue Ridge Cancer Care and the ...

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Harnessing Immunotherapy-Based Strategies for Advanced Non–Small Cell Lung Cancer With Ticiana Leal, MD, and Beth Sandy, MSN, CRNP

Oncology Data Advisor™ · Harnessing Immunotherapy-Based Strategies for Advanced Non–Small Cell Lung Cancer An estimated 236,740 new cases of lung cancer are reported in the United States annually, and 130,180 people die of the disease. Approximately 84% of cases are classified as non–small cell lung cancer (NSCLC) (ACS, 2022). Though new screening procedures have identified more lung cancers at an earlier stage, most patients are still diagnosed at a locally advanced or metast...

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Optimizing Management of Metastatic Squamous Non–Small Cell Lung Cancer With Mark Kris, MD, and Victoria Sherry, DNP, CRNP, AOCNP®

Oncology Data Advisor™ · Optimizing Management of Metastatic Squamous Non-Small Cell Lung Cancer Squamous cell lung carcinoma is a distinct histologic subtype of non–small cell lung cancer (NSCLC) that accounts for approximately 25% to 30% of all NSCLC cases and is associated with approximately 30% shorter survival compared with other subtypes of the disease. Because alterations and mutations for which targeted therapies are approved are uncommon in squamous cell NSCLC, treatment re...

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FDA Approves Nivolumab as Neoadjuvant Therapy for Resectable Non–Small Cell Lung Cancer

 The FDA has approved nivolumab (Opdivo®, Bristol-Myers Squibb) in combination with platinum doublet chemotherapy for the treatment of adult patients with early-stage, resectable non–small cell lung cancer (NSCLC). Nivolumab is a fully human programmed cell death ligand 1 (PD-L1)–targeted antibody, and its use is approved without regard for PD-L1 expression level. "In patients with nonmetastatic NSCLC, surgery has curative potential, but 30% to 80% who undergo resection experience recurrenc...

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World Cancer Day: An Expert Panel Discussion With Thomas Abrams, MD; Ulka Vaishampayan, MD; and Beth Sandy, MSN, CRNP

In honor of World Cancer Day, members of the Oncology Data Advisor (ODA) editorial board gathered to discuss the latest advances and future directions in oncology research. Dr. Thomas Abrams, an Assistant Professor of Medicine at Harvard Medical School shared recent progress in the field of gastrointestinal cancers; Dr. Ulka Vaishampayan, a Professor of Internal Medicine at the University of Michigan Rogel Cancer Center provided insights into current trends in genitourinary cancer research; and Beth Sandy, MSN, CRNP, an outpatient thoracic oncology nurse practitioner at the University of Pennsylvania Abramson Cancer Center, discussed recent and future treatment advances in the field of lung cancer.  

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World Cancer Day: An Expert Panel Discussion With Thomas Abrams, MD; Ulka Vaishampayan, MD; and Beth Sandy, MSN, CRNP

In honor of World Cancer Day, members of the Oncology Data Advisor (ODA) editorial board gathered to discuss the latest advances and future directions in oncology research. Dr. Thomas Abrams, an Assistant Professor of Medicine at Harvard Medical School shared recent progress in the field of gastrointestinal cancers; Dr. Ulka Vaishampayan, a Professor of Internal Medicine at the University of Michigan Rogel Cancer Center provided insights into current trends in genitourinary cancer research; and Beth Sandy, MSN, CRNP, an outpatient thoracic oncology nurse practitioner at the University of Pennsylvania Abramson Cancer Center, discussed recent and future treatment advances in the field of lung cancer.  

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Furthering Clinical Trials and Improving Outcomes for Patients With Lung Cancer: Ross Camidge, MD, PhD

The outcomes of patients with lung cancer have improved significantly in recent years, largely due to the treatment targeting the cancer's specific genetic profile and the impact of immunotherapy, often in different groups of patients. In this interview, Ross Camidge, MD, PhD, Director of Thoracic Oncology at the University of Colorado Cancer Center, discusses the importance of considering multiple factors when deciding on clinical trials for patients. Oncology Data Advisor: When would you recom...

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Utilizing Biomarker Testing to Improve Lung Cancer Survival: Beth Sandy, MSN, CRNP

The survival rate for lung cancer has improved significantly in recent years, largely due to the adoption of biomarker testing and the development of targeted therapies. In this interview in honor of Lung Cancer Awareness Month, Beth Sandy, MSN, CRNP, Outpatient Thoracic Oncology Nurse Practitioner at the University of Pennsylvania Abramson Cancer Center, discusses the importance of utilizing biomarker testing in order to determine treatment options for patients with lung cancer. Oncology Data A...

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Lung Cancer Screening Adherence After Baseline Screening Is Lower Than Reported

Patients who undergo baseline lung cancer screening are less likely to adhere to screening recommendations compared with the screening rates of patients who participate in randomized clinical trials, according to a meta-analysis now published in JAMA Network Open. Undergoing regular cancer screening has been shown to reduce the risk of cancer mortality. Data from the 2018 National Health Interview Survey found that approximately 70% of eligible women underwent breast cancer screening within the ...

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Brigatinib More Effective Than Crizotinib in ALK-Positive Non-Small Cell Lung Cancer

A second interim analysis of the phase 3 ALTA-1L trial shows that brigatinib demonstrates superior results in patients with advanced ALK inhibitor-naive ALK-positive non-small cell lung cancer (NSCLC) compared with crizotinib. Crizotinib is not the most effective therapy for patients with ALK-positive NSCLC, as disease progression occurs frequently in the central nervous system, possibly due to poor drug penetration. In previous phase 1/2 trials, brigatinib, a next-generation ALK inhibitor with ...

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Capmatinib Approved: Metastatic Non-Small Cell Lung Cancer

The FDA has granted accelerated approval to capmatinib (TabrectaTM, Novartis) for adults with metastatic non­-small cell lung cancer (NSCLC) with mutations that lead to mesenchymal-epithelial transition (MET) exon 14 skipping. In addition, the FDA approved the FoundationOne® CDx (F1CDx) assay (Foundation Medicine, Inc.) as a companion diagnostic. Approval was based on the phase 2 GEOMETRY mono-1 trial (NCT02414139), a multicenter, nonrandomized trial evaluating capmatinib in patients with MET ex...

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Lung Cancer Screening Program Websites: Faulty Advertising?

Although lung cancer screening can help to save lives, it is not without significant risks. Patients need to be given information about both benefits and risks so that they can make an informed decision regarding whether to undergo screening. However, an analysis of screening program websites has now shown that many provide a biased, overly positive perspective of screening rather than a well-balanced portrayal of risks and benefits. The National Lung Screening Trial found that screening with lo...

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New Targets in Fight Against Squamous Cell Carcinoma

Researchers have discovered the means by which the protein ΔNp63α drives cell proliferation in various types of squamous cell carcinoma (SCC), revealing an actionable direction for the development of new drug-based SCC treatments. The p63 isoform ΔNp63α, a member of the p53 family of transcription factors, is crucial to a developing embryo's epithelial maintenance and epidermal morphogenesis. After this stage of development, it should play no further role. However, if ΔNp63α becomes active in th...

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Cancer Vaccine Attacks Multiple Targets for Better Results

In a strategy that may prevent tumors from eluding the immune system's attack, researchers have developed a new cancer vaccine capable of targeting multiple members of a cancer-causing family of proteins at once. Because proteins in the melanoma-associated antigen (MAGE-A) family are highly tumor specific and are overexpressed in several types of cancer, they have become a focus of recent immunotherapy research efforts. Yet melanoma and lung carcinoma investigations of MAGE-A3, a MAGE-A isoform ...

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Metastatic Non-Small Cell Lung Cancer: Academic Treatment Settings Improve Survival

Patients with metastatic non-small cell lung cancer (NSCLC) have higher chances of surviving if they are treated in academic medical centers rather than in community-based centers, according to a new study published in the Journal of Thoracic Oncology. Of the approximately 85% of lung cancer patients who are diagnosed with NSCLC, around 40% present with metastatic disease. Metastatic NSCLC is highly difficult to treat and leaves patients with limited chances of survival. However, new treatment s...

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Lung Cancer Risk From Common Blood Pressure Medications

Angiotensin converting enzyme (ACE) inhibitors are effective at controlling high blood pressure, but according to a recent study, they also increase the risk for lung cancer. A research team headed by Laurent Azoulay, PhD, Senior Investigator at the Lady Davis Institute and Associate Professor of Oncology at McGill University in Montreal, Canada, analyzed data from the UK Clinical Practice Research Datalink (CPRD) on 992,061 British patients newly treated with antihypertensive drugs between Janu...

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Pembro/Pemetrexed-Platinum: How Does It Affect Patient QOL?

In patients with previously untreated, metastatic, non-squamous non-small cell lung cancer (NSCLC), pembrolizumab plus pemetrexed-platinum has proven to be an effective treatment compared with pemetrexed-platinum alone in increasing the proportion of patients who experience a complete or partial response, as shown in the KEYNOTE-189 study. Based on the results of this study, the FDA recently approved a new indication for pemetrexed in this combination for the first-line treatment ...

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The Deadly Consequences of Fine Particle Air Pollution

A new study finds an association between fine particulate matter (PM2.5) air pollution and deaths from nine different causes, including cardiovascular disease, cerebrovascular disease, hypertension, dementia, and lung cancer, among others. Furthermore, 99% of PM2.5-associated deaths were linked to levels of PM2.5 exposure currently deemed acceptable by US Environmental Protection Agency (EPA) recommendations. Atmospheric particulate matter with a diameter of less than 2.5 micrometers, PM2.5, is ...

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Racial, Age-Related Disparities in Lung Cancer Treatment

A new study reports that only 62.1% of US patients with lung cancer receive treatment that adheres to guidelines, and elderly and non-Hispanic black patients are disproportionately represented among those whose cancer is undertreated. For the study, now published in Annals of the American Thoracic Society, the researchers evaluated whether 441,812 lung cancer cases in the US National Cancer Database diagnosed between 2010 and 2014 received treatment that adhered to the National Comprehensive Can...

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