Update on Immunotherapeutic Strategies for Advanced Merkel Cell Carcinoma With Shailender Bhatia, MD and Ciara Kelly, MBBCh, BAO

Merkel cell carcinoma is a rare and aggressive neuroendocrine tumor of unknown origin that typically presents in older white and immunocompromised adults. An estimated 2,488 cases are diagnosed in the United States annually (Paulson et al, 2018). The incidence of MCC has risen rapidly during the past few decades, which has been attributed in part to people living longer with increased sun exposure and weakened immune systems, a feature that suggests an infectious origin and warrants further rese...
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Merkel Cell Carcinoma: Pembrolizumab as First-Line Treatment

The second most common cause of skin cancer death, Merkel cell carcinoma (MCC) is a rare and lethal cancer that usually metastasizes quickly. Researchers have discovered that the immunotherapy drug pembrolizumab (Keytruda®), which has already been FDA approved as a second-line treatment for MCC, elicits a better response rate and increased progression-free survival compared with chemotherapy as a first-line treatment for this condition. In this multicenter phase II trial (Cancer Immunotherapy Tr...
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Metastatic Merkel Cell Carcinoma: Treatment Challenges and Best Practices With Paul Nghiem, MD, PhD

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of unknown origin that typically presents in older white and immunocompromised adults. An estimated 1,500 cases are diagnosed in the United States annually. The rapid rise of MCC incidence during the past few decades has been attributed in part to people living longer with increased sun exposure and weakened immune systems, a feature that suggests an infectious origin and warrants further research. Treatment standards are ...
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Pembrolizumab Approved for Merkel Cell Carcinoma

Previously approved for the treatment of several other cancers, including lung, cervical, gastric, liver, head and neck, bladder, and certain types of lymphoma, pembrolizumab (Keytruda®, Merck & Co., Inc.) is now approved for both adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC), a rare skin cancer affecting about 2,000 patients per year. Merkel cell carcinoma is aggressive and challenging to treat, and patients with advanced disease have...
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