HIPEC With Interval Cytoreductive Surgery Improves Survival in Ovarian Cancer

In patients with stage III ovarian cancer, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery significantly improves centrally assessed recurrence-free and overall survival, according to results of a study now published in the International Journal of Gynecological Cancer. By enhancing the penetration of chemotherapy at the peritoneal surface, HIPEC has been found to improve outcomes in patients with advanced ovarian cancer. However, the effi...

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HIPEC With Cytoreductive Surgery Effective in Ovarian Cancer

For patients with stage III epithelial ovarian cancer, adding hyperthermic intraperitoneal chemotherapy (HIPEC) to primary cytoreductive surgery (PCS) increases survival compared with PCS alone, according to results of a retrospective study now published in JAMA Network Open. Of all the gynecologic cancers, ovarian cancer is the most deadly. This may be due in part to the fact that in almost 70% of cases, by the time a patient is first diagnosed with ovarian cancer, it has already spread beyond ...

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Nanoscale Liquid Biopsy Technique Reveals More About Cancer

Something intriguing occurs when nanoparticles come into contact with biological fluids: proteins attach themselves to the nanoparticle surfaces, forming what is called a "protein corona." This phenomenon has now resulted in a technique that could allow doctors and researchers to glean additional information from the blood of cancer patients. When researchers from the University of Manchester extracted injected liposomes—lipid-based nanoparticles used for drug delivery with minimal side effects—...

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Olaparib for BRCA-Mutated Ovarian Cancer: Andrés Poveda, MD

Last weekend, in the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program, Andrés Poveda, MD, presented results of the phase 3 SOLO2/ENGOT Ov-21 trial, reporting that olaparib significantly increased median overall survival compared with placebo in patients with platinum-sensitive BRCA-mutated relapsed ovarian cancer. In this interview with i3 Health, Dr. Poveda, Executive Co-Director of Initia Oncology in Valencia, Spain, discusses the significance of the trial's results...

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Olaparib for BRCA-Mutated Relapsed Ovarian Cancer

In patients with platinum-sensitive BRCA-mutated relapsed ovarian cancer, olaparib maintenance therapy significantly increased median overall survival compared with placebo, according to results of the final analysis of the phase 3 SOLO2/ENGOT Ov-21 trial to be presented this coming weekend in the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program. The trial enrolled 295 patients with BRCA-mutated relapsed ovarian cancer who were previously treated with at least two lin...

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Niraparib Approved for Frontline Maintenance: Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

The FDA has now expanded the approval of niraparib (Zejula®, GlaxoSmithKline) to include maintenance therapy for adults with metastatic epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in complete or partial response to first-line platinum-based chemotherapy, regardless of homologous recombination deficiency (HRD) status. This frontline maintenance approval adds to previous approvals for third-line or later maintenance therapy in these cancers regardless of HRD...

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Reduced Risk of Ovarian Cancer With Low-Dose Aspirin Use

A new study conducted by Moffitt Cancer Center in conjunction with Huntsman Cancer Institute and Harvard T.H. Chan School of Public Health found that women who take low-dose aspirin daily are at lower risk of developing ovarian cancer. The findings, published online by JAMA Oncology, also show that women who take at least 10 tablets per week of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen over many years are at an increased risk of developing ovarian can...

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New Tactic Launches Dual-Pronged Attack on Ovarian Tumor Cells

In a new approach to combatting ovarian cancer, a paper published in Cancer Cell describes an engineered antibody able to launch a dual-pronged assault on tumor cells. A primary difficulty with immunotherapy for ovarian cancer is that therapeutic antibodies cannot effectively penetrate the solid tumor bed. According to senior author Jogender Tushir-Singh, PhD, assistant professor of biochemistry and genetics at the University of Virginia School of Medicine, the solid tumor microenvironment ...

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Ovarian Cancer: Researchers Predict PARP Inhibitor Response

​Researchers have found a way to identify which patients with high-grade serous ovarian carcinoma (HGSOC), the most malignant and most common form of ovarian cancer, will respond to poly (ADP-ribose) polymerase (PARP) inhibitor therapy. The answer to this question, as addressed in a study published in Nature Communications, could allow doctors to tailor patients' therapy on an individual basis, facilitating better treatment responses and increased chances of survival. Mutations of two BRCA genes...

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Current Challenges and Promising Advances in Recurrent Ovarian Cancer With Ursula Matulonis, MD

Ovarian cancer accounts for 5% of cancer deaths among women in the United States and causes more deaths than any other cancer of the female reproductive system. An estimated 22,240 new cases are diagnosed annually, and 14,070 people die of the disease. Relative survival varies by age; women younger than 65 are much more likely to survive 5 years (77%) following diagnosis than women 65 and older (20%). Overall, the 5-year relative survival rate for ovarian cancer patients is 47%. If diagnosed at ...

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New Targets Identified in BRCA-Mutated Cancers

Researchers at Brigham and Women's Hospital have identified two new genes that can impact BRCA2-deficient cancer through "synthetic lethality," which occurs when a combination of deficiencies in two or more genes leads to cell death that would not occur with one deficiency alone. Inactivation of BRCA1 or BRCA2, both important tumor suppressor genes named for their roles in breast cancer, increases a woman's risk of breast cancer by up to 80% and increases her risk of ovarian cancer by around 50%...

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Early-Stage Ovarian Cancer Detected by Blood Test

With a 20% five-year survival rate, advanced ovarian cancer is one of the deadliest diseases. When women are diagnosed in stages I and II, however, the five-year survival rate increases to 90%. Unfortunately, only 15% of ovarian cancer cases are discovered in the early stages due to lack of symptoms and a dearth of tests for ovarian cancer biomarkers. Researchers at the University of Adelaide and Griffith University in Australia have found a potential new method to detect early-stage disease by ...

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Ovarian Cancer: Affordable Care Act Increased Early Diagnosis

According to researchers, expanded access to health insurance as a result of the implementation of the 2010 Affordable Care Act (ACA) led to earlier diagnosis and treatment of ovarian cancer. For the study, results of which were presented at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, the investigators used a difference-in-differences approach to compare stage at diagnosis and time to treatment before and after the ACA between two groups of women with ovarian cancer: th...

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PTUPB: A Key to Hindering Tumor Inflammation

Although chemotherapy is a potent treatment, it sometimes causes dying cancer cells to become inflamed, triggering the growth of more malignant cells. Researchers have discovered a new anti-inflammatory compound that decreases tumor inflammation and reduces cancer growth in ovarian tumors in mice. In these recent developments, published in Proceedings of the National Academy of Sciences, investigators discovered that first-line platinum- and taxane-based chemotherapies fuel a macrophage-derived ...

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The Affordable Care Act: Impact on Ovarian Cancer Diagnosis With Anna Jo Smith, MD, MPH, MSc

The 2010 Affordable Care Act expanded access to health insurance for many Americans. In a study presented at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, Anna Jo Smith, MD, MPH, MSc, and Amanda Nickels Fader, MD, found that the Affordable Care Act led to earlier diagnosis and treatment of ovarian cancer. In this interview with i3 Health, Dr. Smith, a gynecology and obstetrics resident at Johns Hopkins Medicine, discusses the implications of her study's results. What led ...

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Knowledge Gaps Identified in Treating Recurrent Ovarian Cancer With PARP Inhibitors

As the number of treatments for recurrent ovarian cancer expands, confusion may develop over which therapeutic strategy is best to use. Numerous patient factors need to be taken into account when deciding on a treatment plan, such as patient health status, predictive/prognostic markers, disease-free interval, number of lines and agents used previously, toxicities remaining from previous lines of therapy, and the extent of disease relapse. The new research constantly being conducted creates anoth...

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Genital Powder and Ovarian Cancer Risk: No Significant Link

​In recent years, a number of lawsuits have highlighted concerns regarding a possible link between ovarian cancer risk and the use of talc-containing cosmetic powders in the genital area. However, a large pooled analysis now published in JAMA reports no statistically significant association between genital powder use and ovarian cancer. The potential connection between genital powder use and ovarian cancer risk was first investigated because of the relationship between talcum powder and asbestos...

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Niraparib Approved for Advanced HRD-Positive Ovarian Cancer

The FDA has approved niraparib (Zejula®, Tesaro, Inc.) for patients with advanced ovarian, fallopian tube, or primary peritoneal cancer who experience disease progression following three or more lines of chemotherapy. Niraparib is indicated for patients whose tumors are positive for homologous recombination deficiency (HRD). The approval was based on QUADRA (NCT02354586), a multicenter, open-label, single-arm, phase 2 trial that enrolled 463 patients with relapsed, high-grade serous epithelial o...

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Olaparib/Bevacizumab Improves Outcomes in BRCA-Negative Ovarian Cancer

A phase 3 trial reports that olaparib as maintenance therapy in combination with bevacizumab increases progression-free survival (PFS) in patients with newly diagnosed, advanced high-grade ovarian cancer both with and without BRCA mutations. While previous studies have found that maintenance olaparib is associated with improved outcomes in patients with ovarian cancer with BRCA mutations, its efficacy in patients without BRCA mutations had not been confirmed. In the phase 3 PAOLA-1 trial, a team...

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Advanced Gynecologic Cancers: Olaparib Approved for Maintenance Therapy

The FDA has now approved olaparib (Lynparza®, AstraZeneca Pharmaceuticals LP) for maintenance treatment of adults with deleterious or suspected deleterious germline or somatic BRCA-mutated advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer experiencing complete or partial response to first-line platinum-based chemotherapy. Patients are to be selected for therapy using an FDA-approved companion diagnostic, the BRACAnalysis CDx® test (Myriad Genetic Laboratories, Inc.). The ...

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