Delaying Radical Prostatectomy: Risky or Safe?

Patients can safely delay a radical prostatectomy for up to 180 days after diagnosis of high-risk prostate cancer, according to results of a study now published in JAMA Network Open. Using the US National Cancer Database (NCDB), the researchers collected data on 32,184 patients with clinically localized high-risk prostate adenocarcinoma who were diagnosed between the years 2006 and 2016 and who underwent a radical prostatectomy. Patients were categorized into 5 groups according to surgical delay...
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Body Fat Distribution Affects Risk of Prostate Cancer

There is "strong evidence" as classified by the World Cancer Research Fund that obesity is associated with an increased risk of prostate cancer. In order to investigate this further, researchers objectively measured body fat distribution of men and their risk of developing prostate cancer. For this study, called the Age, Gene/Environment Susceptibility-Reykjavik study, results of which were published in Cancer, 1,832 men went through baseline computed tomography (CT) imaging of fat deposition, b...
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EN2 Secretions: Potential New Prostate Cancer Target

Researchers discovered that the transcription factor protein Engrailed-2 (EN2), which forms boundaries and guides neurons in development, also plays a role in cancer: tumors secrete EN2, which is then taken up by the surrounding normal cells, preventing immune invasion. Lead researcher Richard Morgan, PhD, Professor of Molecular Oncology at the University of Bradford, remarked, "For tumors to survive, grow bigger, and spread, they need to control the behavior of cancer cells and the normal cells...
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New Potential Biomarker Discovered for Treatment of Deadly Prostate Cancer

After a successful initial response to prostate cancer treatment targeting the androgen receptor, some patients develop neuroendocrine prostate cancer (NEPC), which is the deadliest subtype of castration-resistant prostate cancer and does not have an effective treatment. In a new study, researchers from the Sanford Burnham Prebys Medical Discovery Institute (SBP) found that protein kinase C lambda/iota (PKCλ/ι) causes metabolic reprogramming that creates favorable conditions for NEPC to grow. Th...
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New Technology Effectively Predicts Prostate Cancer

The most accurate prostate progression prediction technology to date has been developed by researchers from the Icahn School of Medicine at Mount Sinai and the Keck School of Medicine at the University of Southern California. Existing methods of prostate cancer detection include multiparametric magnetic resonance imaging (MRI) and the Prostate Imaging Reporting and Data System Version 2, a five-point scoring scale that categorizes tumors found on the multiparametric MRI. Because they are subject...
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