Skip to main content

Repotrectinib Approved for ROS1-Positive Non–Small Cell Lung Cancer

The FDA has approved repotrectinib (Augtyro™, Bristol Myers Squibb Company) for locally advanced or metastatic ROS1-positive non–small cell lung cancer (NSCLC). This is the first approval for the next-generation ROS1/TRK tyrosine kinase inhibitor (TKI) repotrectinib and is the first FDA approval to include patients with ROS1-positive NSCLC who have previously received a ROS1 TKI, as well as patients who are TKI-naive.   Why it matters: "Repotrectinib is a next-generation ROS1 and TRK TKI th...

Continue reading

ROS1+ Non-Small Cell Lung Cancer: Entrectinib Shows Promise

Results have been strong for phase 1 and 2 clinical trials of entrectinib (RXDX-101), an orally available selective tyrosine kinase inhibitor, in treatment of patients with ROS1-positive non-small cell lung cancer (NSCLC). A ROS1 rearrangement is a chromosomal abnormality where ROS1 has mutated so that it signals cells to continuously survive and multiply, thereby causing cancer. ROS1-positive NSCLC is a distinct molecular subset of NSCLC that occurs in 1% to 2% of lung cancer cases. Compared wi...

Continue reading