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Delaying Radical Prostatectomy: Risky or Safe?

Patients can safely delay a radical prostatectomy for up to 180 days after diagnosis of high-risk prostate cancer, according to results of a study now published in JAMA Network Open. Using the US National Cancer Database (NCDB), the researchers collected data on 32,184 patients with clinically localized high-risk prostate adenocarcinoma who were diagnosed between the years 2006 and 2016 and who underwent a radical prostatectomy. Patients were categorized into 5 groups according to surgical delay...

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Transoral Robotic Surgery Improves Survival in Older Patients With HPV-Related Oropharyngeal Carcinoma

Transoral robotic surgery with pathologic characteristics-guided adjuvant therapy may improve survival outcomes in older patients with human papillomavirus (HPV)-related oropharyngeal carcinoma (OPSCC), according to a retrospective cohort analysis now published in JAMA Otolaryngology–Head & Neck Surgery. Because patients over 70 years of age are underrepresented in clinical trials for HPV-related oropharyngeal cancers, the optimal way to treat these patients remains controversial. Additional...

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Circadian Rhythm Disruption Causes Cancer—But How?

Our circadian rhythm—the biological clock that dictates when we become sleepy or alert—is essential to healthy functioning. A disrupted circadian rhythm is known to wreak havoc on the human body, causing abnormal behavioral and hormonal rhythms, cognitive discrepancies, weight gain, diabetes, increased cell death, and in some cases, cancer. However, the molecular, biochemical, or cellular mechanisms that underlie the effects of circadian rhythm disruption have until now remained a mystery. To be...

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