Recently, the FDA approved melphalan for liver-directed treatment of uveal melanoma. In this interview, Oncology Data Advisor Editorial Board member Dr. Richard Carvajal, Deputy Physician-in-Chief and Director of Medical Oncology at Northwell Health Cancer Institute in New York, discusses the approval and the trial that led to it, as well as share exciting insights on the potential future landscape of this rare disease. Oncology Data Advisor: Welcome to Oncology Data Advisor, a digital re...
The FDA has approved melphalan for injection (Hepzato Kit™/Hepatic Delivery System), containing melphalan (Hepzato™, Delcath Systems, Inc.) as a liver-directed treatment for patients with uveal melanoma with unresectable hepatic metastases affecting ≤50% of the liver. This treatment is permitted for those with no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection or radiation. This application was granted or...
Recently, the FDA granted approval to tebentafusp for the treatment of patients with human leukocyte antigen (HLA)-A*02:01–positive unresectable or metastatic uveal melanoma, marking the first agent to be approved for this rare ocular malignancy. In this interview, Dr. Richard Carvajal, Associate Professor of Medicine at Columbia University Irving Medical Center and editorial board member of Oncology Data Advisor, discusses the practice-changing significance of the approval of tebentafusp and delves further into future directions in the development of treatments for uveal melanoma.
Oncology Data Advisor™ · The Groundbreaking Approval of Tebentafusp for Uveal Melanoma With Richard Carvajal, MD Recently, the FDA granted approval to tebentafusp for the treatment of patients with human leukocyte antigen (HLA)-A*02:01–positive unresectable or metastatic uveal melanoma, marking the first agent to be approved for this rare ocular malignancy. In this interview, Dr. Richard Carvajal, Associate Professor of Medicine at Columbia University Irving Medical Center and edito...
The FDA has approved tebentafusp-tebn (Kimmtrak®, Immunocore) for the treatment of patients with HLA-A*02:01–positive unresectable or metastatic uveal melanoma."Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a one-year overall survival of approximately 50% in patients with metastatic uveal melanoma," wrote Paul Nathan, MD, PhD, Consultant Medical Oncologist at the Mount Vernon Cancer Centre in the United Kingdom, and colleagues in the...
For half of patients with uveal melanoma, this rare cancer of the eye ultimately metastasizes to the liver. Once in the liver, the prognosis is bleak: patients typically live 2 to 9 months after diagnosis. Patients whose cancer has metastasized have few options for treatment. Recently, however, scientists conducting research on various treatments may have discovered the answer: a compound called FR900359 (FR), found in Christmas berry primrose plants of the Ardisia crenata species. With further ...